Two Granulosa-Celled Tumours

The Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours

BACKGROUND Despite their distinct biology, granulosa cell tumours (GCTs) are treated the same as other ovarian tumours. Intriguingly, a recurring somatic mutation in the transcription factor Forkhead Box L2 (FOXL2) 402C>G has been found in nearly all GCTs examined. This investigation aims to identify the pathogenicity of mutant FOXL2 by studying its altered transcriptional targets. METHODS Th...

Unusual and late recurrences in ovarian adult granulosa cell tumours.

Case 1 A 47-year-old woman presented 13 years after laparotomy for a malignant GCT. She had undergone total abdominal hysterectomy, bilateral salpingo-oophorectomy (TAH+BSO) and omentectomy for a stage I disease according to the classifi cation by the Federation of International Society of Gynaecologists and Obstetricians (FIGO). Histology had confi rmed the type and stage of the malignancy. Co...

The Multifaceted Granulosa Cell Tumours—Myths and Realities: A Review

Background. Granulosa cell tumors (GCTs), representing ~2% of ovarian tumours, are poorly understood neoplasms with unpredictable and undetermined biological behaviour. Design. 5 unusual presentations of GCT and a retrospective 14-year (1997-2011) surgical pathology review based on patient sex, age, tumour type and concurrent pathology findings are presented to discuss the "myths and realities"...

Two Tumours Complicating Pregnancy

A Round Celled Sarcoma

His urine was scanty. It was measured from day to day. On the first day it was found to be only 14 ounces in 21 hours. It increased a little afterwards, namely, 30 ounces in 21 hours. When the eyeball was found completely disorganised it was excised on the 24th September 1908, but it was found free from any growth. After this he began to get fever. His temperature ranged at first between" 99? F...